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Once bounded with Ca2 , the vesicles dock and fuse with the presynaptic membrane, and release neurotransmitters into the synaptic cleft by a process known as exocytosis.The neurotransmitters then diffuse across the synaptic cleft and bind to postsynaptic receptors embedded on the postsynaptic membrane of another neuron.There are two families of receptors: ionotropic and metabotropic receptors.

Neurons are cells that are specialized to receive, propagate, and transmit electrochemical impulses.

In the human brain alone, there are over eighty billion neurons.

The undershoot phase occurs because unlike voltage-gated sodium channels, voltage-gated potassium channels inactivate much more slowly.

Nevertheless, as more voltage-gated K channels become inactivated, the membrane potential recovers to its normal resting steady state..

Synaptic plasticity in both excitatory and inhibitory synapses has been found to be dependent upon postsynaptic calcium release Two molecular mechanisms for synaptic plasticity (researched by the Eric Kandel laboratories) involve the NMDA and AMPA glutamate receptors.


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